Insuficiência cardíaca e atividade física: o aumento de enzimas antioxidantes e a melhora da atividade nervosa simpática

Conteúdo do artigo principal

Rodrigo Augusto dos Santos Gonçalves
Vitor Engrácia Valenti
Celso Ferreira
Neif Murad
Luiz Carlos de Abreu

Resumo

A insuficiência cardíaca vem se tornando um problema cada vez maior em saúde pública, e uma das principais causas de internações hospitalares em todo o mundo. Mesmo com os progressos médicos e os avanços tecnológicos atuais, a prevalência da doença aumentou nas últimas cinco décadas. Estudos recentes com animais mostraram que existe uma relação entre hiperatividade simpática na insuficiência cardíaca e aumento do estresse oxidativo sistêmico e central. Este trabalho tem como objetivo analisar, por meio de revisão bibliográfica, os benefícios produzidos pela atividade física em pacientes portadores de insuficiência cardíaca. Foram revisados estudos relacionados ao estresse oxidativo, controle neural da circulação, insuficiência cardíaca e exercício físico entre outubro de 2009 e abril de 2010 nas bases de dados: Medline, Pubmed e Lilacs. As referências eram datadas de 1986 a 2010. Utilizaram-se os seguintes termos: “Oxidative Stress”, “Chronic Heart Failure”, “Baroreflex”, “Nervous System” and “Exercise”. Ratos com insuficiência cardíaca induzida possuem um aumento de espécies reativas de oxigênio na região rostroventrolateral do bulbo, assim como comprometimento na atividade simpática. Alguns estudos sugerem que a atividade física normaliza a atividade simpática por meio de seus mecanismos antioxidantes em seres humanos. Outro aspecto interessante é que a atividade física reduz os níveis plasmáticos de angiotensina II, regula a disfunção do baroreflexo arterial e promove o aumento de enzimas antioxidantes no músculo esquelético de pacientes com insuficiência cardíaca. Portanto, conclui-se que a atividade física é um regime terapêutico não-farmacológico de extrema importância para pacientes com insuficiência cardíaca.

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Referências

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