@article{Lima_Ximenes_Maciel_2022, title={Occurrence of blaKPC gene in clinical isolates of Pseudomonas aeruginosa from Brazil}, volume={47}, url={https://portalnepas.org.br/abcshs/article/view/1646}, DOI={10.7322/abcshs.2020198.1646}, abstractNote={<p><em>Pseudomonas aeruginosa</em> is one of the main microorganisms causing healthcare-related infections. The rise of carbapenem-resistant <em>P. aeruginosa</em> (CRPA) strains has become a serious public health problem. Dissemination of the enzyme <em>Klebsiella pneumoniae</em> carbapenemase (KPC) encoded by the <em>bla<sub>KPC</sub></em> gene cause the inactivation of β-lactam antibiotics being one of the mechanisms involved in this resistance. Given the above, the objective of this review was to evaluate the occurrence of the <em>bla<sub>KPC</sub> </em>gene in clinical isolates of <em>P. aeruginosa</em> in Brazil. For this, the online databases used were: Lilacs, SciELO and PubMed. The search for articles included articles published from 2012 to 2020, using the following keywords: <em>bla<sub>KPC</sub></em> (KPC), <em>Pseudomonas aeruginosa,</em> and Brazil (in Portuguese and English). Initially, 30 publications eligible for inclusion in this review were identified. After the first analysis, two articles were excluded due to duplication. Subsequently, titles and abstracts were evaluated, 15 articles were excluded because they did not fit the theme, and 13 articles that met the inclusion criteria were read in full. In these studies, the presence of the <em>bla<sub>KPC</sub></em> gene was investigated in 566 clinical isolates of <em>P. aeruginosa</em> in Brazil, with 86 (15.2%) positive samples found. Pernambuco was the state with the highest number of articles and positive samples, respectively, 38.5% (5/13), and 65.1% (56/86). This study reinforces the need to investigate the occurrence of this gene in all regions of the country in CRPA, aiming to understand how its dissemination occurs and to promote prevention and therapeutic strategies.</p>}, journal={ABCS Health Sciences}, author={Lima, Jailton Lobo da Costa and Ximenes, Rafael Matos and Maciel, Maria Amélia Vieira}, year={2022}, month={Dec.}, pages={e022306} }