Estudo dos efeitos da fluoxetina e da venlafaxina no comportamento alimentar compulsivo do tipo “binge” em ratos
Conteúdo do artigo principal
Resumo
Objetivo: avaliar a eficácia da fluoxetina e da venlafaxina no tratamento do comportamento alimentar compulsivo tipo “binge” induzido por restrição de espaço, em ratos. Material e método: foram utilizados 120 ratos, subdivididos em grupos de acordo com a droga utilizada (controle, fluoxetina ou venlafaxina), os tipos de alimentação (dieta livre ou regrada) e gaiolas utilizadas (tamanho padrão ou de espaço restrito). Resultados: os ratos mostraram hiperfagia rebote quando foram submetidos à dieta restrita (2 horas/dia por 7 dias). A hiperfagia foi aumentada quando os ratos foram colocados na gaiola de espaço restrito, tendo sua mobilidade diminuída. Apenas o grupo em que foi administrada venlafaxina apresentou diminuição do binge pela restrição de espaço. Conclusão: o tratamento com fluoxetina foi incapaz de alterar o comportamento do tipo binge induzido em ratos, já a venlafaxina, sob as mesmas condições, reduziu este comportamento.
Downloads
Detalhes do artigo
Referências
Weltzin TE, Fernstrom MH, Kaye NH. Serotonin and bulimia nervosa. Nutrition Reviews 1994;52:399-408. http://dx.doi.org/10.1111/j.1753-4887.1994.tb01375.x
American Psychyatry Associaton. Diagnostic and statistical manual of mental disorders (DSM-IV). APA Press 1994.
Campagnolo AM, Barcaro M, Guein YLS et al. Antidepressivos no tratamento farmacológico da bulimia nervosa. Rev Psiquiatr1998;20:61-8.
Peterson CB, Mitchell JE. Psychosocial and pharmacological treatment of eating disorders: a reviews of research findings. JCLP/ In session: psychotherapy in practice 1999;55:685-97.
Mitchell JE, Hatsukami D, Eckert ED et al. Characteristics of 275 patients with bulimia. Am J Psychiatr 1985;142:482-5.
Kendler KS, Maclean C, Neale M et al. The genetic epidemiology of bulimia nervosa. Am J Psychiatry 1991; 145:1627-37.
Goldstein DJ, Wilson MG, Thompsom VL. Long-term fluoxetine treatment of bulimia nervosa. Br J Psychiatry 1995;166:660-6. http://dx.doi.org/10.1192/bjp.166.5.660
Goldbloom DS, Olmsted MP. Pharmachotherapy of bulimia nervosa with fluoxetine: assessment of clinically significant attitudinal change. Am J Psychiatry 1993;150:770-4.
Jimerson DS, Wolfe BE, Metzger ED et al. Decreased serotonin function in bulimia nervosa. Arch Gen Psychiatry 1997;54:529-34. http://dx.doi.org/10.1001/archpsyc.1997.01830180043005
Mitchell JE, Zwaan M, Crow S. Psychopharmachology of eating disorders. Ballieres Clin Psychiatry 1997;3:217-34.
Walsh BT, Devlin MJ. Psychopharmacology of anorexia nervosa, bulimia nervosa, and binge eating. Psychopharmacology: the fourth generation of progress 1994;1581-9.
Advokat C, Kutlesic V. Pharmacotherapy of the eating disorders: A commentary. Neurosci Biobehav Rev 1995; 19:59-66. http://dx.doi.org/10.1016/0149-7634(94)00044-2
Wurtman JJ, Wurtman RJ. Fenfluramine and fluoxetine spare protein consumption while supressing caloric intake in rats. Science 1997;198:1178-80. http://dx.doi.org/10.1126/science.929195
Wheadon DE, Wilson MG, Rampey AH et al. Fluoxetine in the long-term treatment of bulimia nervosa. Clin Res 1991;39:769A.
Schatzberg AF. New indications for antidepressants. J Clin Psychiat 2000;61:9-17.
Maj J, Rogóz Z. Pharmacological effects of venlafaxine, a new antidepressant, given repeatedly on the a1-adrenergic, dopamine and serotonin systems. J Neural Transm 1999;106:197-211. http://dx.doi.org/10.1007/s007020050151
Dawson LA, Nguyen HQ, Geiger A. Effects of venlafaxine on extracellular concentrations of 5-HT and noradrenaline in the rat frontal cortex: augmentation via 5-HT receptor antagonism. Neuropharmacol 1999;38:1153-63. http://dx.doi.org/10.1016/S0028-3908(99)00052-0
Rudolph R, Entuash R, Derivan A. Early clinical response in depression to venlafaxine hydrochloride. Biol Psychiat 1991;29:630.
Mucci M. Rebocetine: a review of antidepressant tolerability. J Psychopharmacol 1997;11:33-7.
Wardle J. Compulsive eating and dietary restraint. Br J Clin Psych 1987;26:47-55. http://dx.doi.org/10.1111/j.2044-8260.1987.tb00722.x
Tushi RJ. From dietary restraint to binge eating: some theoretical considerations. Appetite 1990;14:105-9. http://dx.doi.org/10.1016/0195-6663(90)90004-R
Ruderman AJ. Dietary restraint : a theoretical and empirical role. Psychol Bull 1986;99:249-62. http://dx.doi.org/10.1037/0033-2909.99.2.247
Herman CP, Polivy J. Studies of eating in non-dieters. American Psychiatry Press 1988;95-111.
Inoue K, Kiriike N, Okuno M et al. Prefrontal and striatal dopamine metabolism during enhanced rebound hyperphagia induced space restriction – a rat model of binge eating. Biol Psychiatry 1998;44:1329-36. http://dx.doi.org/10.1016/S0006-3223(97)00518-0
Leibowitz SF. The role of serotonin in eating disorders. Drugs 1990;39:33-48. http://dx.doi.org/10.2165/00003495-199000393-00005
Blundell JE. Serotonin and appetite. Neuropharmacology 1984;23:1537-51. http://dx.doi.org/10.1016/0028-3908(84)90098-4
Fernstrom JD. Diet, food intake regulation and brain serotonin: an overview. In: Bray D, Ryan D. The Science of food regulation. Louisiana State University Press 1992;2:195-209.
Russem GFM. Bulimia nervosa: an ominous variant of anorexia nervosa. Psychol Med 1979;9:429-48. http://dx.doi.org/10.1017/S0033291700031974
Walsh BT, Devlin MJ. Pharmacotherapy of bulimia nervosa and binge eating disorder. Addictive behaviour 1995;20:757-64. http://dx.doi.org/10.1016/0306-4603(95)00091-7
Faiburn CG, Agras WS, Wilson GT. The research on the treatment of bulimia nervosa: practical and theoretical implications. In: Anderson A, Kenney S. The biology of feast and famine. Academic Press 1992;137-40.
Okuno M, Kiriike N, Inoue K et al. Effects of space restriction on rat feeding and serotonin metabolism following restricted scheduled feeding. Bull Jpn Neurochem 1986;31:249-62.
Stolkes PE, Holtz A. Fluoxetine tenth anniversary update: the progress continues. Clin Ther 1997;19:1135-250. http://dx.doi.org/10.1016/S0149-2918(97)80066-5
Ferguson JM, Feighner JP. Fluoxetine-induced weight loss in overweight non-depressed humans. Int J Obes 1987; 11:163-70.
Lawton CL, Wales JK, Hill AJ et al. Serotoninergic manipulation, meal-induced satiety and eating pattern: effect of fluoxetine in obese female subjects. Obes Res 1995;3:345-56. http://dx.doi.org/10.1002/j.1550-8528.1995.tb00160.x
Bolden-Watson C, Richelson E. Blockade by newly-developed antidepressants of biogenic amine uptake into rat brain synaptosomes. Life Sci 1993;52:1023-9. http://dx.doi.org/10.1016/0024-3205(93)90194-8
Gartside SE, Umbers V, Sharp T. Inhibition of 5-HT cell firning in the DRN by non-selective 5-HT reuptake inhibitors: studies on the role of 5-HT1a autoreceptors and noradrenergic mechanisms. Psychopharmacology 1997;130:261-8. http://dx.doi.org/10.1007/s002130050238