Main Article Content
Introduction: Oral lichen planus is an inflammatory condition that affects the stratified squamous epithelium of the oral mucosa. It occurs more frequently in female patients and it is rarely observed in children, adolescents, or young adults. This study aims to report a case of oral lichen planus in a young patient with a nine-year follow-up. Case report: A 19-year-old man reported to the Dentistry Department with a complaint of an asymptomatic white lesion on the dorsum and left lateral border of his tongue, which had appeared a few weeks before. Two weeks later, a second lesion, very similar to the previous one, appeared on the central region of his tongue. An incisional biopsy was performed. The histological slides were stained with hematoxylin-eosin and the expression of interleukin-1beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) was assessed by immunohistochemistry. No pharmacological treatment was prescribed. The clinical and histopathological findings were suggestive of oral lichen planus. The IL-1β/TNF-α expression was low. There was a spontaneous regression of the lesions after approximately one year. The nine-year follow-up showed no signs of recurrence. Conclusion: This case presents atypical features such as the age of the patient and the spontaneous remission of the lesions.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY) that allows others to share and adapt the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Cascone M, Celentano A, Adamo D, Leuci S, Ruoppo E, Mignona MD. Oral lichen planus in childhood: a case series. Int J Dermatol. 2017;56(6):641-52. https://doi.org/10.1111/ijd.13571
Mareeswari GH, Kiran MS, Sherubin JE, Joy ET, Manchil PRD, Aravind BS. The myriad presentations of lichen planus. Int J Med Dent Case Reports. 2017;4(1):1-4. https://doi.org/10.15713/ins.ijmdcr.55
Gupta S, Jawanda MK. Oral lichen planus: an update on etiology, pathogenesis, clinical presentation, diagnosis and management. Indian J Dermatol. 2015;60(3):222-9. https://doi.org/10.4103/0019-5154.156315
Gorouhi F, Davari P, Fazel N. Cutaneous and mucosal lichen planus: a comprehensive review of clinical subtypes, risk factors, diagnosis, and prognosis. Sci World J. 2014;2014:742826. https://doi.org/10.1155/2014/742826
Hulimavu SR, Mohanty L, Tondikulam NV, Shenoy S, Jamadar S, Bhadranna A. No evidence for Helicobacter pylori in oral lichen planus. J Oral Pathol Med. 2014;43(8):576-8. https://doi.org/10.1111/jop.12194
Belkacem Chebil R, Oueslati Y, Marzouk M, Fredj FB, Oualha L, Douki N. Oral lichen planus and lichenoid lesions in Sjogren's Syndrome patients: A Prospective Study. Int J Dent. 2019;2019:1603657. https://doi.org/10.1155/2019/1603657
Sandhu SV, Sandhu JS, Bansal H, Dua V. Oral lichen planus and stress: An appraisal. Contemp Clin Dent. 2014;5(3):352-56. https://doi.org/10.4103/0976-237X.137946
Belal MH. Management of symptomatic erosive-ulcerative lesions of oral lichen planus in an adult Egyptian population using Selenium-ACE combined with topical corticosteroids plus antifungal agent. Contemp Clin Dent. 2015;6(4):454-60. https://doi.org/10.4103/0976-237x.169837
Muller S. Oral lichenoid lesions: distinguishing the benign from the deadly. Mod Pathol. 2017;30(s1):S54-67. https://doi.org/10.1038/modpathol.2016.121
Cassol-Spanemberg J, Rivera-Campillo MER, Otero-Rey EM, Estrugo-Devesa A, Jané-Salas E, López-López J. Oral lichen planus and its relationship with systemic diseases. A review of evidence. J Clin Exp Dent. 2018;10(9):e938-e44. https://doi.org/10.4317/jced.55145
Humberto JSM, Pavanin JV, Rocha M, Motta ACF. Cytokines, cortisol, and nitric oxide as salivary biomarkers in oral lichen planus: a systematic review. Braz Oral Res. 2018;32:e82. https://doi.org/10.1590/1807-3107bor-2018.vol32.0082
Cheng YS, Gould A, Kurago Z, Fantasia J, Muller S. Diagnosis of oral lichen planus: a position paper of the American Academy of Oral and Maxillofacial Pathology. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122(3):332-54. https://doi.org/10.1016/j.oooo.2016.05.004
Chainani-Wu N, Madden E, Lozada-Nur F, Silverman Jr S. High-dose curcuminoids are efficacious in the reduction in symptoms and signs of oral lichen planus. J Am Acad Dermatol. 2012;66(5):752-60. https://doi.org/10.1016/j.jaad.2011.04.022
Eisen D. The clinical features, malignant potential, and systemic associations of oral lichen planus: A study of 723 patients. J Am Acad Dermatol. 2002;46(2):207-14. https://doi.org/10.1067/mjd.2002.120452
Hasan S, Mansoori S, Ansari MI, Siddiqui S. Oral lichen planus in an 8-year-old child: A case report with a brief literature review. J Oral Maxillofac Pathol. 2020;24:S128-34. https://doi.org/10.4103/jomfp.JOMFP_343_19