Efeitos pleiotrópicos das estatinas na sepse

Silvana Menegoto Nogueira Di Giusto, Kelly Cristina Batista de Souto Queiroz, Rodrigo Daminello Raimundo, Luiz Carlos de Abreu, Mônica Akemi Sato

Resumo


O objetivo do presente estudo foi revisar os efeitos da terapia com estatinas em pacientes com quadro de sepse. Foi realizada uma busca bibliográfica de artigos na base de dados MEDLINE/PubMed, SciELO e LILACS, no período de publicação delimitado entre 2009 e 2013. Foram incluídos artigos referentes a ensaios clínicos randomizados controlados e estudos de coorte observacionais clínicos. Foram encontrados diversos estudos clínicos e observacionais que investigaram o efeito do uso de estatinas em infecções e em sepse, tanto de uso contínuo pré-hospitalar (com ou sem interrupção durante internação) ou com início imediato pós-internação. Alguns estudos descrevem prováveis efeitos positivos e benéficos da terapia com estatinas no quadro de sepse, dentre eles a melhora dos parâmetros inflamatórios e da taxa de mortalidade, porém, esses resultados não se sustentam quando são aplicados métodos estatísticos que levam em conta diferentes variáveis, tais como idade, sexo, comorbidades e gravidade da doença. Até o momento nenhum estudo demonstrou evidências sólidas e significativas quanto à redução de mortalidade e morbidade no quadro séptico associado ao uso de estatinas, indicando que seu efeito benéfico e protetor ainda não foi plenamente delimitado, sendo necessários mais estudos que confirmem os resultados até agora encontrados. 


Palavras-chave


sepse; anticolesterolemiantes; choque séptico; hidroximetilglutaril CoA redutases; inflamação

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Referências


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DOI: https://doi.org/10.7322/abcshs.v39i1.249

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Direitos autorais 2014 Silvana Menegoto Nogueira Di Giusto, Kelly Cristina Batista de Souto Queiroz, Rodrigo Daminello Raimundo, Luiz Carlos de Abreu, Mônica Akemi Sato