The action of Metaloproteinases in the Atherosclerotic Diseases

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Álvaro Luís Müller da Fonseca
Fernanda Washington de Mendonça Lima
Ricardo David Couto


Cardiovascular diseases represent the main cause of morbidity and mortality in the world and are epidemic events involving the atherosclerosis and coronary artery disease in particular. There are a wide variety of factors and markers associated with the development and aggravation of these diseases, including atherosclerosis. Subclinical Atherosclerosis can be determined by serum inflammatory markers present in the atherogenic process. Such markers can take a direct or indirect indicator role on atherosclerotic cardiovascular disease. The extracellular matrix metalloproteinases are biomarkers closely related into modifying and remodeling of vascular wall and other tissues and can represent predictive value patterns to support diagnosis. This review discusses the function and types of matrix metalloproteinases and its use as an indicator of support for the diagnosis of atherosclerosis.


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Fonseca, Álvaro L. M. da, Lima, F. W. de M., & Couto, R. D. (2014). The action of Metaloproteinases in the Atherosclerotic Diseases. ABCS Health Sciences, 39(3).
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