Concentrations of IL-6, TNF-α and MCP-1 in children with excess of body mass

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Juliano Magalhães Guedes
José Botempo Mamêde Neto
Jéssica de Fátima Xavier dos Santos
Rafael Frata Cândido
Alynne Chrystian Ribeiro Andaki
Edmar Lacerda Mendes


This systematic review aimed to verify the relationship of IL-6, TNF-α and MCP-1 concentrations in children with excess of body mass. The databases PUBMED, SciELO, LILACS and Periódicos Capes were consulted retrospectively for the last 6 years (2009 to 2014) using combined of keywords like inflammation, IL-6, TNF-α, MCP-1 combined with children and schoolers. A total of 21 articles were analyzed. We found an association between overweight/obesity with IL-6, TNF-α and MCP-1 in 73.3% (11/15), 80% (12/15) and 60% (3/5) in the studies that analyzed these markers, respectively. Children with excess of body mass have high concentrations of IL-6, TNF-α and MCP-1 resulting in chronic systemic inflammation and increasing the risk of developing other cardiovascular diseases.


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Guedes, J. M., Mamêde Neto, J. B., Santos, J. de F. X. dos, Cândido, R. F., Andaki, A. C. R., & Mendes, E. L. (2015). Concentrations of IL-6, TNF-α and MCP-1 in children with excess of body mass. ABCS Health Sciences, 40(2).
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