Erectile dysfunction after COVID-19 infection: A cross-sectional study in a male sample from Brazil

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Gabriel Marton Bressa
Vinicius Eduardo Lopes
Vinicius Buturi Machado
Cesar Alexsandro Arbigaus
Matheus Caires dos Santos
Ricardo Mendes Silveira
Bernardo Sobreiro
Thelma Skare
Renato Nisihara

Abstract

Introduction: COVID-19 infection may cause erectile dysfunction due to local viral infection and impairing mental health. Objective: To analyze the erectile function in Brazilian sample patients during pandemics with and without COVID-19 infection and compare with results from a sample obtained before the pandemic. Methods: Internet survey with epidemiologic questions, data on COVID-19 infection, and the International Index for Erectile Function (IIEF). Patients were divided into those with and without infections. A control group with results obtained before the pandemic was also included. Results: Four hundred twenty-two males were studied 210 with data obtained before the pandemic; 208 with data obtained during the pandemic (84 with COVID-19 infection and 124 without). Patients with COVID-19 infection had worse results of IIEF than those without (in the pandemics and before pandemics) with p=0.01 and used more sexual stimulants (p=0.02). The results were worse in the first month after the infection. Conclusion: Patients with COVID-19 infection had impairment in erectile function that is more severe in the first month after infection.

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How to Cite
Bressa, G. M., Lopes, V. E., Machado, V. B., Arbigaus, C. A., Santos, M. C. dos, Silveira, R. M., Sobreiro, B., Skare, T., & Nisihara, R. (2024). Erectile dysfunction after COVID-19 infection: A cross-sectional study in a male sample from Brazil. ABCS Health Sciences, 49, e024223. https://doi.org/10.7322/abcshs.2023006.2261
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Original Articles

References

Xie J, Tong Z, Guan X, Du B, Qiu H. Clinical characteristics of patients who died of coronavirus disease 2019 in China. JAMA Network Open. 2020;3(4):e205619. https://doi.org/10.1001/jamanetworkopen.2020.5619

Hamilton LD, Meston CM. Chronic stress, and sexual function in women. J Sex Med. 2013;10(10):2443-54. https://doi.org/10.1111/jsm.12249

Gore AC, Attardi B, DeFranco DB. Glucocorticoid repression of the reproductive axis: effects on GnRH and gonadotropin subunit mRNA levels. Mol Cell Endocrinol. 2006;256:(1-2):40-8. https://doi.org/10.1016/j.mce.2006.06.002

Izawa S, Saito K, Shirotsuki K, Sugaya N, Nomura S. Effects of prolonged stress on salivary cortisol and dehydroepiandrosterone: a study of a two-week teaching practice. Psychoneuroendocrinology. 2012;7(6):852-8. https://doi.org/10.1016/j.psyneuen.2011.10.001

Jeckel CMM, Lopes RP, Berleze MC, Luz C, Feix L, Argimon IIL, et al. Neuroendocrine and immunological correlates of chronic stress in “strictly healthy” populations. Neuroimmunomodulation. 2010;17(1):9-18. https://doi.org/10.1159/000243080

Scialo F, Daniele A, Amato F, Pastore L, Matera MG, Cazzola M, et al. ACE2: the major cell entry receptor for SARS-CoV-2. Lung. 2020;198(6):867-77. https://doi.org/10.1007/s00408-020-00408-4

Adamyan L, Elagin V, Vechorko V, Stepanian A, Dashko A, Doroshenko D, et al. A review of recent studies on the effects of SARS-CoV-2 infection and SARS-CoV-2 vaccines on male reproductive health. Med Sci Monit. 2022;21:28:e935879. https://doi.org/10.12659/MSM.935879

Rosen RC, Cappelleri JC, Smith MD, Lipsky J, Peña BM. Development, and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res. 1999;11(6):319-26. https://doi.org/10.1038/sj.ijir.3900472

Nisihara R, Heil Junior LJ, Fagundes FG, Sobreiro B, Campos APB, Simioni J, et al. Erectile Dysfunction, Testosterone Levels and Disease Activity in Ankylosing Spondylitis Patients. Urology. 2021;153:210-14. https://doi.org/10.1016/j.urology.2021.01.008

Harirugsakul K, Wainipitapong S, Phannajit J, Paitoonpong L, Tantiwongse K. Erectile dysfunction among Thai patients with COVID-19 infection. Transl Androl Urol. 2021;10(12):4376-83. https://doi.org/10.21037/tau-21-807

Sansone A, Mollaioli D, Ciocca G, Colonnello E, Limoncin E, Balercia G, et al. "Mask up to keep it up": Preliminary evidence of the association between erectile dysfunction and COVID-19. Andrology. 2021;9(4):1053-9. https://doi.org/10.1111/andr.13003

Salar R, Erbay G, Şanlı A, Yavuz U, Kandemir E, Turel H, et al. Effect of COVID-19 infection on the erectile function. Andrology. 2023;11(1):10-16. https://doi.org/10.1111/andr.13315

Xiong J, Lipsitz O, Nasri F, Lui LMW, Gill H, Phan L, et al. Impact of COVID-19 pandemic on mental health in the general population: A systematic review. J Affect Disord. 2020;277:55-64. https://doi.org/10.1016/j.jad.2020.08.001

Hamilton LD, Meston CM. Chronic stress, and sexual function in women. J Sex Med. 2013;10(10):2443-54. https://doi.org/10.1111/jsm.12249

Gore AC, Attardi B, Franco DB. Glucocorticoid repression of the reproductive axis: effects on GnRH and gonadotropin subunit mRNA levels. Mol Cell Endocrinol. 2006;256:40-8. https://doi.org/10.1016/j.mce.2006.06.002

Izawa S, Saito K, Shirotsuki K, Sugaya N, Nomura S. Effects of prolonged stress on salivary cortisol and dehydroepiandrosterone: a study of a two-week teaching practice. Psychoneuroendocrinology. 2012;37(6):852-8. https://doi.org/10.1016/j.psyneuen.2011.10.001

Harirugsakul K, Wainipitapong S, Phannajit J, Paitoonpong L, Tantiwongse K. Erectile dysfunction after COVID-19 recovery: A follow-up study. PLoS One. 2022;17(10):e0276429. https://doi.org/10.1371/journal.pone.0276429

Manalo TA, Biermann HD, Patil DH, Mehta A. The temporal association of depression and anxiety in young men with erectile dysfunction. J Sex Med. 2022;19(2):201-6. https://doi.org/10.1016/j.jsxm.2021.11.011

Kresch E, Achua J, Saltzman R, Khodamoradi K, Arora H, Ibrahim E, et al. COVID-19 endothelial dysfunction can cause erectile dysfunction: histopathological, immunohistochemical, and ultrastructural study of the human penis. World J Mens Health. 2021;39:466-9. https://doi.org/10.5534/wjmh.210055

Flaifel A, Guzzetta M, Occidental M, Najari BB, Melamed J, Thomas KM, et al. Testicular changes associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Arch Pathol Lab Med. 2021;145(1):8-9. https://doi.org/10.5858/arpa.2020-0487-LE

Sansone A, Romanelli F, Gianfrilli D, Lenzi A. Endocrine evaluation of erectile dysfunction. Endocrine. 2014;46(3):423-30. https://doi.org/10.1007/s12020-014-0254-6

Maggio M, Basaria S, Ceda GP, Ble A, Ling SM, Bandinelli S, et al. The relationship between testosterone and molecular markers of inflammation in older men. J Endocrinol Invest. 2005;28(11 Suppl Proceedings):116-9.

Mohamad NV, Wong SK, Wan Hasan WN, Jolly JJ, Nur-Farhana MF, Ima-Nirwana S, et al. The relationship between circulating testosterone and inflammatory cytokines in men. Aging Male. 2019;22(2):129-40. https://doi.org/10.1080/13685538.2018.1482487