Epidemiological characterization of patients submitted to hematopoietic stem cell transplantation at a reference center in Curitiba, Paraná, Brazil, 2011-2015

Abstract

Introduction: Hematopoietic stem cell transplantation (HSCT) is the only alternative for the treatment of some diseases. However, there is a shortage of studies in Brazilian population. Objective: To identify the profile of patients submitted to HSCT at the Hospital de Clínicas da Universidade Federal do Paraná (HC/UFPR), between 2011 and 2015, based on demographic variables, diagnosis, duration of hospitalization and the mortality ration in the institution. Methods: Time Series Studies research based on data from the Hospital Information System. The trend in the distribution of proportions over the years was evaluated through Cochran‑Armitage test and negative binomial regression. The presence of serial autocorrelation was tested by the Durbin‑Watson test. Results: From 2011-2015 Paraná was responsible for 9.2% of HSCT performed in Brazil. HC/UFPR accounted for 46.0% of these procedures performed in Paraná. There were no significant variations in the sex distribution (p=0.788) and number of HSCT (p=0.213). 59.5% of the patients were from PR, 49.4% were between 0 and 17 years old, 79.9% were white, and 63.5% were male. The allogeneic HSCT was the most performed procedure (88.5%). 58.5% were hospitalized from 31 to 60 days (mean=37.6 days). 9.1% died. Acquired aplastic anemia was the most common underlying disease (31.9%). Conclusion: HSCT is a procedure of high cost and complexity. The study and the understanding of the determinants of its success are of extreme importance for the best planning, risk estimation and elaboration of public health policies.