Ferritin: a biomarker of cardiovascular diseases in diabetic patients
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Abstract
Introduction: Diabetes Mellitus (DM) is a clinical condition characterized by hyperglycemia default in secretion and/or insulin resistance. Objective: Check the correlation between markers of inflammation, high sensitivity C-reactive protein (hs-CRP), ferritin and lipids in diabetic patients. Methods: We carried out the analysis of lipid profiles of 50 type 2 diabetic patients, with an average of four years of diagnosis. We analyzed the plasma concentration of glucose, total cholesterol, HDL cholesterol, LDL cholesterol, VLDL cholesterol, triglycerides, ferritin and hs-CRP. Results: The study showed a strong positive correlation between ferritin and hs-CRP (r=0.85), between ferritin and LDL cholesterol and triglycerides (r=0.91, r=0.91), moderate positive correlation to total cholesterol (r=0.63); moderate negative for HDL cholesterol (r=0.38). Conclusion: The results indicate that ferritin shows a strong positive correlation with hs-CRP, triglycerides and LDL cholesterol that, when considered in combination, suggest the suspicion of active inflammatory process and a greater chance of atherosclerosis in these patients.
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